We want to help you understand the background of Lidocaine as it is an important ingredient in TPR20. To do this we have posted links to a key group of peer reviewed research papers so you can read for yourselves just how safe and effective this compound really is. These are not from our research but independent, academically verified studies from a wide range of internationally respected journals.
Lidocaine is a local anesthetic which was developed in Sweden in the 1940s to replace Procaine. Procaine created allergies when used and a safer, hypoallergenic replacement was sought. Lidocaine is hypoallergenic.
Lidocaine was an immediate success in dental use for its safety and rapid action and is still in use today. The use of Lidocaine in general pain relief has been limited until now as most pain treatments have been oral pills such as aspirin and other NSAIDs.
The majority of doctor’s visits are for the treatment of pain. Pain relief medication is made available either by prescription or as over-the-counter products. The usefulness of many of the currently available medications taken orally for pain is increasingly countered by side effects and the threat of addiction. These limitations have led to the search for new and effective agents that can relieve pain and be used safely with multimodal treatments. Lidocaine fits that requirement.
Lidocaine is one of the most researched medications. TPR20 uses lidocaine in a cream directly on the skin and directly on the place where there is pain. There is a large body of research specifically focused on topically applied Lidocaine, whether in a skin patch, gel or cream, in the same quantity, 5%, as TPR20 uses.
- Gabra, B.H., Systemic absorption of topical lidocaine in a bone marrow transplant recipient with hepatic sinusoidal obstruction syndrome. Am J Health-Syst Pharm—Vol 68 Jan 15, 2011.
- Zimmermann, J et al. Proof of Systemic Safety of a Lidocaine Ointment in the Treatment of Patients with Anorectal Pain. Arzneimittel-Forschung (Drug Research) 2007;57(1):12–19.
- Nestor, M.S., Safety of occluded 4% liposomal lidocaine cream. Journal of Drugs in Dermatology, July-August, 2006.
- Gammaitoni A.R. et al. Pharmacokinetics and safety of continuously applied lidocaine patches 5%. Am J Health-Syst Pharm—Vol 59 Nov 15, 2002.
- Gammaitoni A.R. et al. Safety and Tolerability of the Lidocaine Patch 5%, a Targeted Peripheral Analgesic: A Review of the Literature. J Clin Pharmacol 2003;43:111-117.
Prepared by Rowan Hamilton. MINH, Dip Phyt. MSCS. Research Division. Trans Research Labs.
